Drug abuse may appear with or without withdrawal or tolerance. Tolerance and withdrawal indicate physical dependence. A key concern in evaluating addiction is usually if a person is unable to quit using the harmful substance . Often individuals who are dependent on a drug do not have insight into their inability to avoid drug make use of and falsely believe they could stop if they wished to. This is called denial.The issued statements offer broad safety of a technology system developed by Dr. Maurizio Zanetti, Professor of Director and Medication of the Laboratory of Immunology at the UC San Diego Moores Cancer Center. The technology platform offers a method for providing a nucleic acid molecule like a DNA vaccine into B cells ; this method is normally termed somatic transgene immunization or STI. It allows for the development of specific vaccines for the treating various tumors and infectious illnesses. The technology uses the patient’s very own B cells for antigen creation, as well for antigen demonstration. STI introduces into a host the ‘blueprint’ for vaccine molecules in a manner that mimics viral attacks without the infectious danger.