Within the bigger, 8. Allelic association testing revealed seven SNPs within MUC2 which were significantly associated with either familial interstitial pneumonia or idiopathic pulmonary fibrosis . MUC2 is usually within a genomic area harboring four gel-forming mucin genes . Although recombination hotspots located between MUC6 and MUC2 and within the proximal portion of MUC5B have been reported, markers within MUC5AC and MUC2 exhibit strong linkage disequilibrium.16 Thus, MUC2 and MUC5AC were chosen for resequencing by using the oligonucleotide primers listed in Tables S5 and S6, respectively, in the Supplementary Appendix.Since hepatitis doesn’t do anything to biliary cells that didn’t quite make sense, Willenbring said Right now there’s a fresh way to look at it, he suggests. As hepatocytes and their genomes become disarrayed by disease, Willenbring says, they might activate oncogenes in much the same way their experiment did, causing the cells to change identity and be cancerous. Having proven that NOTCH and AKT are the triggers in this tumor-inducing process, Chen and her group are now hunting for therapies.