2-year advanced melanoma survival benefit with dabrafenib, trametinib combination By Shreeya Nanda, Senior medwireNews Reporter Updated outcomes from the COMBI-v trial present significantly improved overall and progression-free of charge survival with first-line dabrafenib in addition trametinib weighed against vemurafenib in patients with advanced melanoma. The results of the stage III trial comprising individuals with BRAF V600E/K mutation-positive unresectable or metastatic melanoma were presented at the European Malignancy Congress in Vienna, Austria, by Caroline Robert, from the Institut Gustave Roussy in Paris, France. A previous interim analysis with a median follow-up of 11 weeks showed a substantial improvement in OS with dabrafenib and trametinib, described Robert in her presentation, so much so the trial was terminated early and patients in the vemurafenib group had been permitted to crossover online pharmacy .
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