Alcohol – the worst medication! By Dr Ananya Mandal, MD A new study shows that alcohol misuse is by considerably the most severe habit to have when compared to other recreational drug habits like that of marijuana, crack or heroin. Neuropharmacologist David Nutt, of Imperial College London who is also a previous British government medication advisor and his team rated 20 different drugs on a level that takes into account the various harms caused by a drug. Medications are rated on the nine harms a drug causes to a person and seven harms a drug causes to the culture.Nevertheless, as Drs. Donal O’Carroll and Alexander Tarakhovsky report in an upcoming issue of G&D, Ago2’s defining characteristic can be surprisingly nonessential for its role in hematopoiesis and miRNA biogenesis. O’Carroll, Tarakhovsky and co-workers generated transgenic mice harboring mutated variations of Ago2 in their bone marrow. The researchers discovered that Ago2 is, indeed, quite necessary for normal bloodstream cell advancement. Its endonulcease activity, nevertheless, is not. The scientists could actually restore erythropoiesis in Ago2-deficient mice by expressing a mutated version of Ago2 that lacks its endonuclease activity, thus demonstrating that the role of Ago2 in the hematopoietic system is certainly independent of its slicer activity. Rather, Dr.