The objective of widespread EHR adoption, as envisioned by the Obama administration in 2008, was to permit a changeover from volume-structured to value-based payments: a digital infrastructure was needed for measuring quality. At the right time, however, less than 17 percent of physician methods were using EHRs, and their systems lacked necessary data-capture capabilities often. Given the high up-front costs and uncertainty regarding future returns, financial and cultural hurdles to adoption had been formidable.Adjustments in the expression of this micro RNA may as a result be a quantitative biomarker of response in lung chemoprevention studies, they say. RRM predicts shorter survival Dr Giovanna Dal Bello and co-workers report that expression degrees of ribonucleotide reductase subunit 2 predict shorter survival in sufferers whose non-small cell lung cancer had been surgically taken out. In 82 sufferers, the Italian group found that RRM2 was an unbiased prognostic marker of shorter survival. The difference in overall survival between sufferers with high or low RRM2 amounts was clinically relevant, stated Dr Dal Bello from the National Institute for Cancers Analysis in Genoa, Italy.