Key accomplishments include 59 initiatives implemented across city agencies, improved pedestrian safety at a lot more than 100 redesigned street intersections, 1,000 regional businesses embracing age-friendly procedures, and four neighborhood-level Ageing Improvement Districts that produce visible community improvements based on consultation with regional older adults. NEW YORK was lately named as having the Greatest Age-friendly Initiative in the globe, by the International Federation on Aging.Eitner, T. Feldkamp, D. Fouque, R.R. Furman, O. Gaber, M. Herthelius, M. Hourmant, D. Karpman, Y. Lebranchu, C. Mariat, J. Menne, B. Moulin, J. Ogawa, G. Remuzzi, T. Richard, R. Sberro-Soussan, B. Severino, N.S. Sheerin, A. Trivelli, L.B. Zimmerhackl, T. Goodship, and C.1,2 This syndrome is caused by defects in regulation of the complement system. These defects are inherited, acquired, or both, plus they result in chronic, uncontrolled activation of the complement system1-4 that leads to platelet, leukocyte, and endothelial-cell activation and systemic thrombotic microangiopathy.1,5-9 Affected patients possess a lifelong risk of systemic scientific complications of thrombotic microangiopathy, including damage to multiple organ systems .7,8,13 Within 12 months after a diagnosis of the syndrome, up to 65 percent of individuals treated with plasma exchange or infusion maintain permanent renal damage, possess progression to ESRD, or die.14,15 Combined liver and kidney transplantation may normalize complement regulation in patients with certain genetic defects, 16 but it is associated with substantial morbidity and mortality, including a mortality of 14 percent in the short term.9,17,18 Eculizumab , a terminal complement inhibitor, is a humanized monoclonal antibody that binds with high affinity to the human being C5 complement proteins and blocks the era of proinflammatory C5a and C5b-9.19-25 It really is approved for the treating paroxysmal nocturnal hemoglobinuria.