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16 in the journal Discomfort. Brain abnormalities have already been observed in various other long-term chronic pain circumstances. Apkarian's study is the first to show brain structure abnormalities certainly are a marker of a predisposition to the chronic discomfort, not a total consequence of living with it. The lead author of the analysis is Ali Mansour, M.D., formerly a postdoctoral fellow in Apkarian's lab. Apkarian's research focuses on the partnership between chronic discomfort and the brain. One of is own previous studies showed chronic pain sufferers lose gray matter quantity as time passes. Chronic pain is among the most expensive health care conditions in the U.S.